Prenatal diagnosis of congenital human cytomegalovirus infection

Prenat Diagn. 1994 Oct;14(10):903-6. doi: 10.1002/pd.1970141002.


Fifteen fetuses at risk of congenital human cytomegalovirus (HCMV) infection underwent prenatal diagnosis at 16-30 weeks' gestation by a combination of amniocentesis and fetal blood sampling. HCMV was isolated from the amniotic fluid in six patients, but HCMV-specific IgM was detected in only three of them. Two of the nine neonates, who were delivered following a negative prenatal diagnosis, had congenital HCMV infection diagnosed by virus isolation in the urine. The interval from infection to prenatal testing was 3 and 4 weeks in the two false-negative cases and > or = 7 weeks in the true-positive cases. Although timely testing for HCMV infection allows the option of termination of pregnancy, it may be flawed by false-negative results.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amniocentesis
  • Amniotic Fluid / virology
  • Antibodies, Viral / blood
  • Cytomegalovirus / immunology
  • Cytomegalovirus / isolation & purification
  • Cytomegalovirus Infections / blood
  • Cytomegalovirus Infections / congenital*
  • Cytomegalovirus Infections / diagnosis*
  • False Negative Reactions
  • Female
  • Fetal Blood / enzymology
  • Fetal Blood / immunology
  • Fetal Diseases / blood
  • Fetal Diseases / diagnosis*
  • Gestational Age
  • Humans
  • Immunoglobulin M / blood
  • Infant, Newborn
  • Pregnancy
  • Prenatal Diagnosis*
  • gamma-Glutamyltransferase / blood


  • Antibodies, Viral
  • Immunoglobulin M
  • gamma-Glutamyltransferase