The clinical efficacy of Rev-Eyes in reversing the effects of pupillary dilation

J Am Optom Assoc. 1993 Sep;64(9):634-6.


Background: Pupillary dilation to perform binocular indirect ophthalmoscopy has become a routine part of optometric practice. Many patients find the resulting photophobia and incapacity of near vision to be an inconvenience. Rev-Eyes (0.5% dapiprazole HCl) is a new alpha-antagonist reported to reverse the effects of pupillary dilation in approximately one hour. This study was designed to evaluate the usefulness of Rev-Eyes in a routine clinical setting.

Methods: Seventy-nine subjects free of eye disease that ranged in age from 21 to 40 years received 0.5% proparacaine, 2.5% phenylephrine, and 1.0% tropicamide in each eye. Rev-Eyes was administered to 61 subjects. Eighteen control subjects received 5% NaCl. Effects on pupil diameter, accommodation, and distance and near visual acuity were measured. Conjunctival vasodilation, corneal stippling, patient comfort, and intraocular pressure (IOP) were also evaluated.

Results: Our results confirm that a statistically significant reduction in pupil diameter is achieved 60 minutes after installation of Rev-Eyes. However, no significant improvement was obtained in any of the other functional aspects measured

Conclusions: Our data suggest limited utility for Rev-Eyes with a young population. The recovery rate of near visual acuity and amplitude of accommodation is identical with or without Rev-Eyes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Accommodation, Ocular / drug effects
  • Adrenergic alpha-Antagonists / therapeutic use*
  • Adult
  • Female
  • Humans
  • Male
  • Mydriasis / drug therapy*
  • Ophthalmic Solutions
  • Piperazines
  • Pupil / drug effects*
  • Triazoles / therapeutic use*
  • Visual Acuity / drug effects


  • Adrenergic alpha-Antagonists
  • Ophthalmic Solutions
  • Piperazines
  • Triazoles
  • dapiprazole