Antiretroviral therapy for adult HIV-infected patients. Recommendations from a state-of-the-art conference. National Institute of Allergy and Infectious Diseases State-of-the-Art Panel on Anti-Retroviral Therapy for Adult HIV-Infected Patients

JAMA. 1993 Dec 1;270(21):2583-9. doi: 10.1001/jama.270.21.2583.


This document summarizes recommendations from a state-of-the-art conference convened to evaluate the role of nucleoside analogue reverse transcriptase inhibitors in the treatment of human immunodeficiency virus (HIV) infection. Data from controlled clinical trials of zidovudine, didanosine, and zalcitabine were reviewed by an expert panel, which then formulated guidelines to assist clinicians and HIV-infected patients in the use of these agents. Recommendations were framed in the context of clinical scenarios for patients with asymptomatic HIV infection who have not had prior antiretroviral therapy; those with signs and symptoms of HIV-related disease who have not received prior therapy; clinically stable patients who are tolerating initial zidovudine therapy; patients experiencing clinical progression while on zidovudine therapy; and those who are intolerant of antiretroviral therapy. The panel concluded that physicians need to integrate up-to-date scientific knowledge with other relevant needs to improve the care of HIV-infected patients.

Publication types

  • Review

MeSH terms

  • Adult
  • CD4-Positive T-Lymphocytes
  • Clinical Trials as Topic
  • Didanosine / standards
  • Didanosine / therapeutic use
  • Dideoxynucleosides / standards*
  • Dideoxynucleosides / therapeutic use*
  • Drug Resistance
  • Guidelines as Topic
  • HIV Infections / drug therapy*
  • HIV Infections / immunology
  • Humans
  • Leukocyte Count
  • Zalcitabine / standards
  • Zalcitabine / therapeutic use
  • Zidovudine / standards
  • Zidovudine / therapeutic use


  • Dideoxynucleosides
  • Zidovudine
  • Zalcitabine
  • Didanosine