Mouse Hox genetic functions

Curr Opin Genet Dev. 1993 Aug;3(4):621-5. doi: 10.1016/0959-437x(93)90098-a.


Functional analysis of the genetic roles of the mammalian Hox homeobox family has not been facilitated by the analysis of disease-associated or classically derived mutant loci. However, an increasing number of mouse Hox mutations, generated by homologous recombination, have now demonstrated that the Hox genes are key components in regulating the patterning of axial structures.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone and Bones / embryology
  • Brain / embryology
  • Branchial Region / embryology
  • Embryonic and Fetal Development / genetics
  • Genes, Homeobox / physiology*
  • Mice / embryology
  • Mice / genetics*