Reducing atherogenic risk in hyperlipemic humans with flax seed supplementation: a preliminary report

J Am Coll Nutr. 1993 Oct;12(5):501-4. doi: 10.1080/07315724.1993.10718342.

Abstract

The effect on serum lipids of a flax seed supplement consisting of three slices of flax seed-containing bread and 15 g of ground flax seed was studied in 15 hyperlipemic subjects on long-term intake (800 IU/day) of vitamin E. The flax seed, which was high in alpha-linolenic acid and fiber, and which has been reported to lower serum cholesterol in elderly subjects, was provided in a 3-month feeding trial. Serum total and low-density lipoprotein cholesterol levels were reduced significantly; high-density lipoprotein cholesterol did not change during flax seed consumption. Thrombin-stimulated platelet aggregation decreased with the supplement. Serum lipid oxidation products decreased significantly during the washout period.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / blood
  • Adult
  • Arteriosclerosis / etiology
  • Arteriosclerosis / prevention & control*
  • Bread
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Dietary Fiber / therapeutic use*
  • Edible Grain
  • Female
  • Humans
  • Hyperlipidemias / blood
  • Hyperlipidemias / complications
  • Hyperlipidemias / diet therapy*
  • Lipid Peroxidation
  • Male
  • Middle Aged
  • Platelet Aggregation
  • Seeds*
  • Thiobarbituric Acid Reactive Substances / analysis
  • Triglycerides / blood
  • Vitamin E / blood
  • Vitamin E / therapeutic use
  • alpha-Linolenic Acid / therapeutic use*

Substances

  • Cholesterol, HDL
  • Cholesterol, LDL
  • Dietary Fiber
  • Thiobarbituric Acid Reactive Substances
  • Triglycerides
  • alpha-Linolenic Acid
  • Vitamin E
  • Adenosine Triphosphate