Increased Serum Concentrations of Soluble Tumor Necrosis Factor Receptors in HIV-infected Individuals Are Associated With Immune Activation

J Acquir Immune Defic Syndr (1988). 1994 Jan;7(1):79-85.

Abstract

Serum concentrations of soluble tumor necrosis factor receptors (sTNF-Rs) were measured in 61 human immunodeficiency virus (HIV)-infected individuals. Thirty-five percent of these had increased serum concentrations of sTNF-R type I (p55) (sTNF-R55) and 82% had increased concentrations of sTNF-R type II (p75) (sTNF-R75). The extent of the increase of sTNF-R75 was greater in more advanced HIV infection (p = 0.046) as it was measured by dividing the 61 individuals into two groups according to the median of the CD4+ T-cell count. However, the increase in concentrations of sTNF-R55 in the group with a CD4+ T-cell count below the median was only moderate and did not reach statistical significance. A strong correlation was found between sTNF-R75 and the soluble immune activation markers beta 2-microglobulin (rs = 0.74, p < 0.0001) and urinary neopterin (rs = 0.67, p < 0.0001), and a less strong correlation was found with interferon-gamma (rs = 0.51, p = 0.0001). The correlations observed for sTNF-R55 were also significant but were always weaker than that of sTNF-R75. A weak inverse correlation was found between the number of CD4+ T cells and sTNF-R75 (rs = -0.33, p = 0.012), but no such correlation was observed with sTNF-R55. Our findings suggest that increased concentrations of serum sTNF-Rs in HIV infection are linked to immune activation, in which synergistic actions of interferon-gamma and the TNF-alpha system are likely to play an important role.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biopterin / analogs & derivatives
  • Biopterin / urine
  • CD4-Positive T-Lymphocytes
  • Cross-Sectional Studies
  • Female
  • HIV Infections / blood
  • HIV Infections / immunology*
  • Humans
  • Immunity, Active
  • Interferon-gamma / blood
  • Leukocyte Count
  • Male
  • Middle Aged
  • Neopterin
  • Receptors, Tumor Necrosis Factor / analysis
  • Receptors, Tumor Necrosis Factor / biosynthesis*
  • beta 2-Microglobulin / analysis

Substances

  • Receptors, Tumor Necrosis Factor
  • beta 2-Microglobulin
  • Biopterin
  • Neopterin
  • Interferon-gamma