Control points in early T-cell development

Immunol Today. 1993 Nov;14(11):547-53. doi: 10.1016/0167-5699(93)90186-O.


Intrathymic T-cell differentiation involves the generation, expansion and selection of distinct T-lymphocyte subsets. While positive and negative selection have been a focal point of T-cell development, these events represent the final stages in a complicated sequence of differentiation steps. Here, Dale Godfrey and Albert Zlotnik summarize recent advances in our understanding of early T-cell development and describe five 'control points' that identify key events in this sequence.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology
  • Cell Differentiation
  • Gene Rearrangement, T-Lymphocyte / immunology
  • Humans
  • Lymphocyte Activation / immunology*
  • Mice
  • Receptors, Antigen, T-Cell, alpha-beta / immunology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes, Regulatory / immunology
  • Thymus Gland / immunology


  • Receptors, Antigen, T-Cell, alpha-beta