Single-breath nitric oxide measurements in asthmatic patients and smokers

Lancet. 1994 Jan 15;343(8890):146-7. doi: 10.1016/s0140-6736(94)90935-0.


Exhaled nitric oxide (NO) concentrations were measured in asthmatic outpatients and in non-smoking and smoking healthy controls. In single exhalations, NO showed a peak suggestive of airway origin in both controls and asthmatic patients. The peak NO concentration was higher in asthmatic patients and lower in smokers than in non-smoking controls (p < 0.05). The findings support a role for NO in the host defence response in asthma and suggest that NO measurements can discriminate between different types of lung disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asthma / metabolism*
  • Asthma / physiopathology
  • Breath Tests
  • Female
  • Humans
  • Male
  • Nitric Oxide / analysis*
  • Respiration / physiology
  • Smoking / metabolism*
  • Smoking / physiopathology


  • Nitric Oxide