Abstract
Neuropeptide Y (NPY) and the endogenous kappa-opioid receptor ligand, dynorphin (dyn), stimulate feeding when injected centrally in the rat. Norbinaltorphimine (norBNI, 25 nmol) reduced the feeding response to NPY (2.4 nmol) by 67% (P < 0.02). An additive effect of dynorphin and NPY was seen on food intake (saline 0.8 +/- 0.1, dyn 1.9 +/- 0.4, NPY 6.1 +/- 1.4, dyn and NPY 9.7 +/- 2.2). A component of NPY-induced feeding may be mediated by kappa-opioid neuronal systems.
MeSH terms
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Animals
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Cerebral Ventricles / drug effects
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Cerebral Ventricles / physiology*
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Drug Administration Schedule
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Dynorphins / administration & dosage
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Dynorphins / pharmacology*
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Feeding Behavior / drug effects*
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Injections, Intraventricular
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Male
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Naltrexone / administration & dosage
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Naltrexone / analogs & derivatives*
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Naltrexone / pharmacology
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Neuropeptide Y / administration & dosage
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Neuropeptide Y / pharmacology*
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Rats
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Rats, Wistar
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Receptors, Opioid, kappa / antagonists & inhibitors*
Substances
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Neuropeptide Y
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Receptors, Opioid, kappa
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norbinaltorphimine
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Naltrexone
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Dynorphins