The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides

Life Sci. 1994;54(5):PL63-8. doi: 10.1016/0024-3205(94)00796-9.

Abstract

The protection of stomach and duodenum in conjecture with anti-inflammatory effect was demonstrated for a novel 15 amino acid peptide, coded BPC 157, a fragment of the recently discovered gastric juice peptide BPC. BPC 157 (i.p./i.g.) was investigated in rats in comparison with several reference standards in three experimental ulcer models (48 h-restraint stress, subcutaneous cysteamine, intragastrical 96% ethanol ulcer tests) (pre-/co-/post-treatment). Only BPC 157 regimens were consistently effective in all of the tested models. On the other hand, bromocriptine, amantadine, famotidine, cimetidine and somatostatin were ineffective (restraint stress). A dose-dependent protection (cysteamine) and/or partial positive effect (related to treatment conditions) (ethanol), was obtained with glucagon, NPY and secretin whereas CCK/26-30/was not effective. Based on Monastral blue studies BPC 157 beneficial effect appears to be related to a strong endothelial protection.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cysteamine*
  • Disease Models, Animal
  • Dopamine Agents / pharmacology*
  • Duodenal Ulcer / drug therapy*
  • Duodenal Ulcer / etiology
  • Ethanol*
  • Female
  • Gastrointestinal Hormones / pharmacology*
  • Histamine H2 Antagonists / pharmacology*
  • Male
  • Molecular Sequence Data
  • Peptide Fragments / pharmacology*
  • Proteins / pharmacology*
  • Rats
  • Rats, Wistar
  • Stomach Ulcer / drug therapy*
  • Stomach Ulcer / etiology
  • Stress, Physiological / complications

Substances

  • Dopamine Agents
  • Gastrointestinal Hormones
  • Histamine H2 Antagonists
  • Peptide Fragments
  • Proteins
  • Ethanol
  • Cysteamine
  • BPC 157