T cell subsets involved in immunity against polyoma virus-induced tumors

Virology. 1994 Feb;198(2):714-6. doi: 10.1006/viro.1994.1084.


Lymphocyte subsets involved in the rejection of polyoma virus-induced tumors were studied. Depletion of CD4+ and CD8+ T cells as well as natural killer cells was performed in mice using monoclonal antibodies or anti-asialo GM1 anti-serum. Both CD4+ and CD8+ T cell subsets were found to be necessary for the rejection of polyoma virus-induced tumors, while natural killer cells played a minor, if any, role.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology
  • CD8 Antigens / immunology
  • Cell Division
  • Immunity, Cellular*
  • Killer Cells, Natural / immunology
  • Mice
  • Mice, Inbred CBA
  • Papillomavirus Infections / immunology*
  • T-Lymphocyte Subsets / immunology*
  • Tumor Virus Infections / immunology*


  • CD8 Antigens