Cytomegalovirus reactivation and tumour necrosis factor

Lancet. 1994 Jan 29;343(8892):268-9. doi: 10.1016/s0140-6736(94)91116-9.

Abstract

Tumour necrosis factor-alpha (TNF) stimulates cytomegalovirus (CMV) activity in a transfected human monocytic cell line. We assessed whether this finding is relevant in vivo by evaluating the frequency of active CMV infection in patients with diseases that enhance plasma TNF. In septic disease, peripheral blood mononuclear cells of almost all patients studied were positive for CMV. Furthermore, CMV antigenaemia and enhanced plasma TNF occurred in many patients with liver cirrhosis, common variable immunodeficiency, and B-cell chronic lymphocytic leukaemia. Thus, TNF may have a central role in CMV reactivation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antigens, Viral / blood*
  • Case-Control Studies
  • Common Variable Immunodeficiency / blood
  • Common Variable Immunodeficiency / complications
  • Cytomegalovirus Infections / blood*
  • Cytomegalovirus Infections / complications
  • Cytomegalovirus Infections / microbiology
  • Cytomegalovirus* / growth & development
  • Cytomegalovirus* / immunology
  • Female
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • Interleukin-6 / blood
  • Leukemia, Lymphocytic, Chronic, B-Cell / blood
  • Leukemia, Lymphocytic, Chronic, B-Cell / complications
  • Leukocytes, Mononuclear / microbiology*
  • Liver Cirrhosis / blood
  • Liver Cirrhosis / complications
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Recurrence
  • Sepsis / blood*
  • Sepsis / complications
  • Sepsis / mortality
  • Tumor Necrosis Factor-alpha / analysis*
  • Virus Activation*

Substances

  • Antigens, Viral
  • Interleukin-6
  • Tumor Necrosis Factor-alpha