A comparison of digoxin concentration--time curves before and after open-heart surgery

J Int Med Res. 1993 May-Jun;21(3):147-53. doi: 10.1177/030006059302100305.


The effects of open heart surgery on serum digoxin concentration--time curves were investigated in 10 cardiac patients receiving 0.25 mg/day digoxin. Blood samples were obtained from the patients immediately before and 1, 2, 3, 5, 8, 16 and 24 h after digoxin administration, both before open-heart surgery and 7 days after surgery. Serum digoxin concentrations, determined by fluorescence polarization immuno-assay, significantly (P < 0.05) increased after surgery, as did the maximum serum concentrations and the areas under the concentration-time curves. After surgery there was a significant increase in the serum gamma-glutamyl transferase concentration and a significant reduction in the total protein concentration. A reduction of digoxin dose may be appropriate for patients who have undergone open-heart surgery.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Blood Proteins / metabolism
  • Cardiac Surgical Procedures*
  • Digoxin / administration & dosage
  • Digoxin / blood*
  • Female
  • Fluorescence Polarization
  • Humans
  • Male
  • Middle Aged
  • Postoperative Period
  • Time Factors
  • gamma-Glutamyltransferase / blood


  • Blood Proteins
  • Digoxin
  • gamma-Glutamyltransferase