Expression of epidermal growth factor receptor in invasive transitional cell carcinoma of the urinary bladder. A multivariate survival analysis

Am J Clin Pathol. 1994 Feb;101(2):166-76. doi: 10.1093/ajcp/101.2.166.


Epidermal growth factor receptor (EGFR) immunoreactivity was evaluated in 85 cases of invasive transitional cell carcinoma of the bladder. The impact of EGFR staining on patient survival was compared with tumor stage, histologic grade, immunoreactivity for c-erb B-2 and proliferating cell nuclear antigen, flow cytometrically determined S-phase fraction and DNA ploidy, abnormal expression of blood-group-related antigens, and patient blood type. Using a new monoclonal anti-EGFR antibody reactive in formalin-fixed tissue, the authors found a significant correlation between EGFR expression and high tumor stage, and between EGFR expression and poor patient outcome. However, EGFR expression as a predictor of prognosis was not independent of stage. An intriguing association between patient blood type and patient survival was noted. Other indices did not predict patient outcome after data were adjusted for stage.

Publication types

  • Comparative Study

MeSH terms

  • ABO Blood-Group System / analysis
  • Aged
  • Aged, 80 and over
  • Antibodies, Monoclonal
  • Carcinoma, Transitional Cell / chemistry*
  • Carcinoma, Transitional Cell / epidemiology*
  • Carcinoma, Transitional Cell / ultrastructure
  • DNA, Neoplasm / analysis
  • DNA, Neoplasm / genetics
  • ErbB Receptors / analysis*
  • ErbB Receptors / immunology
  • Female
  • Flow Cytometry
  • Humans
  • Immunohistochemistry
  • Isoantigens / analysis
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Neoplasm Invasiveness
  • Neoplasm Staging
  • Nuclear Proteins / analysis
  • Ploidies
  • Prognosis
  • Proliferating Cell Nuclear Antigen
  • Proto-Oncogene Proteins / analysis
  • Receptor, ErbB-2
  • S Phase
  • Survival Analysis
  • Urinary Bladder Neoplasms / chemistry*
  • Urinary Bladder Neoplasms / epidemiology*
  • Urinary Bladder Neoplasms / ultrastructure


  • ABO Blood-Group System
  • Antibodies, Monoclonal
  • DNA, Neoplasm
  • Isoantigens
  • Nuclear Proteins
  • Proliferating Cell Nuclear Antigen
  • Proto-Oncogene Proteins
  • ErbB Receptors
  • Receptor, ErbB-2