Clinical application of low reactive level laser therapy (LLLT) for atopic dermatitis

Keio J Med. 1993 Dec;42(4):174-6. doi: 10.2302/kjm.42.174.


Patients with atopic dermatitis (AD) were treated with diode low reactive level laser therapy (LLLT), and the following results were obtained. 1) Itchy sensation decreased in 79 of 112 cases (71%) after this therapy. 2) Skin eruptions improved in 69 of 112 cases (62%). 3) There were no side effects during and after LLLT. 4) Major histocompatibility complex (MHC) class II antigen and inter-cellular adhesion molecule (ICAM)-1 expression on epidermal cells decreased after the therapy. 5) The number of CD1 positive epidermal dendritic cells did not significantly change before and after LLLT.

MeSH terms

  • Adolescent
  • Adult
  • Cell Adhesion Molecules / analysis
  • Child
  • Child, Preschool
  • Dermatitis, Atopic / immunology
  • Dermatitis, Atopic / radiotherapy*
  • Female
  • Histocompatibility Antigens Class II / analysis
  • Humans
  • Intercellular Adhesion Molecule-1
  • Laser Therapy*
  • Male
  • Middle Aged
  • Semiconductors


  • Cell Adhesion Molecules
  • Histocompatibility Antigens Class II
  • Intercellular Adhesion Molecule-1