Subnormal serum concentration of 1,25-vitamin D in human immunodeficiency virus infection: correlation with degree of immune deficiency and survival

J Infect Dis. 1994 Apr;169(4):889-93. doi: 10.1093/infdis/169.4.889.

Abstract

Vitamin D metabolites, immunologic, virologic, and clinical parameters, and survival time were determined in 22 asymptomatic human immunodeficiency virus (HIV)-infected patients (CDC stage II/III), 31 symptomatic HIV-infected patients (CDC stage IV), and 28 HIV-seronegative controls. Significantly lower serum levels of 1,25-vitamin D (1,25D) were found in symptomatic patients (median, 34 pg/mL; 25th-75th percentile, 21-45) compared with controls (49 pg/mL; 39-59) and asymptomatic patients (45 pg/mL; 42-50). In HIV-infected subjects, the serum level of 1,25D was positively correlated with CD4+ cell counts in peripheral blood (r = .35, P < .05) and negatively correlated with the level of serum neopterin (r = -.36, P < .01). HIV-infected patients with abnormally low 1,25D (< 25 pg/mL) also had shorter survival times than other HIV-infected subjects (P < .01). Low 1,25D levels did not appear to be related to vitamin D deficiency.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / blood
  • Acquired Immunodeficiency Syndrome / complications
  • Acquired Immunodeficiency Syndrome / drug therapy
  • Acquired Immunodeficiency Syndrome / mortality
  • Biopterin / analogs & derivatives
  • Biopterin / blood
  • CD4-Positive T-Lymphocytes
  • Calcitriol / blood*
  • Follow-Up Studies
  • HIV Infections / blood*
  • HIV Infections / complications
  • HIV Infections / drug therapy
  • HIV Infections / mortality
  • Humans
  • Ketoconazole / therapeutic use
  • Leukocyte Count
  • Neopterin
  • Nutrition Disorders / complications
  • Proportional Hazards Models
  • Survival Analysis
  • T-Lymphocytes, Regulatory

Substances

  • Biopterin
  • Neopterin
  • Calcitriol
  • Ketoconazole