Peptide therapy for diabetes in NOD mice

Lancet. 1994 Mar 19;343(8899):704-6. doi: 10.1016/s0140-6736(94)91582-2.


NOD mice spontaneously develop autoimmune diabetes that mimics insulin-dependent diabetes mellitus (IDDM) in man. A peptide of the 60 kDa heat shock protein (hsp60), designated p277, can serve as a target for diabetogenic T-cell clones, and diabetes was prevented by using the p277 peptide to turn off anti-p277 immunity early in life. We report that the p277 peptide, administered once, can arrest the autoimmune process even after it is far advanced. Successful therapy was associated with down-regulation of the autoimmune process and regression of islet inflammation. Thus the immune system is responsive to manipulation by a specific signal even in the face of a virulent, full-blown autoimmune process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / immunology
  • Animals
  • Autoimmunity / drug effects
  • Blood Glucose / drug effects
  • Chaperonin 60
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / prevention & control*
  • Down-Regulation / drug effects
  • Female
  • Heat-Shock Proteins / immunology
  • Heat-Shock Proteins / therapeutic use*
  • Humans
  • Mice
  • Mice, Inbred NOD


  • Blood Glucose
  • Chaperonin 60
  • Heat-Shock Proteins