Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

Immunol Today. 1994 Jan;15(1):19-26. doi: 10.1016/0167-5699(94)90021-3.


Interleukin 13 (IL-13) is a recently described protein secreted by activated T cells which is a potent in vitro modulator of human monocyte and B-cell functions. The data, reviewed here by Gerard Zurawski and Jan de Vries, shows that IL-13 shares biological activities with IL-4, their genes are closely linked in both the human and mouse genomes, and there is sequence homology between IL-13 and IL-4 proteins. Although the cloned IL-4 receptor protein (IL-4R) does not bind IL-13, it appears that the functional IL-4R and IL-13R share a common subunit that is important for signal transduction.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Interleukin-13
  • Interleukin-4 / physiology*
  • Interleukins / physiology*
  • Leukocytes, Mononuclear / physiology*
  • Mice
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid


  • Interleukin-13
  • Interleukins
  • Interleukin-4