Rapidly progressing atrophy of medial temporal lobe in Alzheimer's disease

Lancet. 1994 Apr 2;343(8901):829-30. doi: 10.1016/s0140-6736(94)92028-1.


The symptoms of Alzheimer's disease are associated with pathological change and loss of neurons in the medial temporal lobe. By yearly temporal-lobe-oriented computed tomograms the average rate of atrophy of the medial temporal lobe was 15.1% per year (95% CI 10.0, 20.2) in 20 patients with histopathologically, confirmed Alzheimer's disease and 1.5% (0.2, 2.8) in 47 healthy ageing controls. Such excessive atrophy presumably reflects the vulnerability of the medial temporal lobe to a catastrophic event, probably a pathological cascade process. Thus, Alzheimer's disease may not be due simply to an acceleration of normal ageing but, rather, is the consequence of a true disease process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / diagnostic imaging
  • Alzheimer Disease / pathology*
  • Alzheimer Disease / psychology
  • Atrophy
  • Cognition
  • Humans
  • Longitudinal Studies
  • Temporal Lobe / diagnostic imaging
  • Temporal Lobe / pathology*
  • Tomography, X-Ray Computed