A Drosophila melanogaster homologue of the T-cell oncogene HOX11 localises to a cluster of homeobox genes

Gene. 1994 Apr 20;141(2):225-9. doi: 10.1016/0378-1119(94)90576-2.

Abstract

The human homeobox gene HOX11 has been identified at the site of a chromosomal translocation in a subset of T-cell acute leukaemias. In the mouse genome, the hox11 family consists of at least three related genes, each of which possesses a highly conserved homeobox. To assist in elucidating the roles of this gene, a homologue was studied from Drosophila melanogaster. This gene, 311, shares similar identity to all three murine family members and contains the threonine residue in helix 3 of the homeodomain characteristic of the Hox11 family. It maps to a cluster of NK-homeobox genes which function in muscle development. Gene 311 exhibits a similar temporal pattern of expression to the NK genes in this cluster. Therefore, 311 may constitute part of a homeobox cluster in which the genes are both co-ordinately regulated and functionally related.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blotting, Northern
  • Chromosome Mapping
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / growth & development
  • Genes, Homeobox*
  • Genes, Insect*
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell / genetics
  • Mice
  • Molecular Sequence Data
  • Multigene Family
  • RNA, Messenger / analysis
  • Sequence Alignment
  • Sequence Homology, Amino Acid

Substances

  • RNA, Messenger

Associated data

  • GENBANK/Z22959