Seasonal variation in the onset of Wegener's granulomatosis, polyarteritis nodosa and giant cell arteritis

J Rheumatol. 1993 Sep;20(9):1524-6.


Objective: The hypothesis of a seasonal pattern in the onset of symptoms for some vasculitides has been raised in previous small studies.

Methods: Using the data collected by the American College of Rheumatology (ACR) Subcommittee on Classification of Vasculitis, we specifically tested for a higher proportion of onset of symptoms in winter, lower in summer, and intermediate for the other seasons for polyarteritis nodosa (PAN) and Wegener's granulomatosis. We also tested for a higher proportion of onset of symptoms in the spring-summer months for giant cell arteritis (GCA).

Results and conclusions: The results of our study support the hypothesis of a seasonal trend for the onset of symptoms of Wegener's granulomatosis (p = 0.04) as described previously. No seasonal pattern was found for the other vasculitides studied (PAN and GCA).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Giant Cell Arteritis / physiopathology*
  • Granulomatosis with Polyangiitis / physiopathology*
  • Humans
  • Polyarteritis Nodosa / physiopathology*
  • Seasons*