A New Arylpiperazine Antipsychotic With High D2/D3/5-HT1A/alpha 1A-adrenergic Affinity and a Low Potential for Extrapyramidal Effects

J Med Chem. 1994 Apr 15;37(8):1060-2. doi: 10.1021/jm00034a003.

MeSH terms

  • Animals
  • Antipsychotic Agents / chemical synthesis
  • Antipsychotic Agents / metabolism*
  • Antipsychotic Agents / pharmacology
  • Dogs
  • Humans
  • Molecular Structure
  • Piperazines / chemical synthesis
  • Piperazines / metabolism*
  • Piperazines / pharmacology
  • Raclopride
  • Rats
  • Receptors, Adrenergic, alpha / metabolism*
  • Receptors, Dopamine / metabolism*
  • Receptors, Dopamine D2 / metabolism
  • Receptors, Dopamine D3
  • Receptors, Serotonin / metabolism*
  • Salicylamides / metabolism

Substances

  • Antipsychotic Agents
  • DRD3 protein, human
  • Drd3 protein, rat
  • Piperazines
  • Receptors, Adrenergic, alpha
  • Receptors, Dopamine
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • Receptors, Serotonin
  • Salicylamides
  • Raclopride
  • mazapertine succinate