Can expression of CD45RO, a T-cell surface molecule, be used to detect congenital infection?

Lancet. 1994 May 21;343(8908):1259-60. doi: 10.1016/s0140-6736(94)92153-9.


Exclusion or confirmation of congenital infection can be difficult in newborn infants. The presence of an infective organism in a fetus leads to activation of fetal T lymphocytes. We have examined expression of isoforms of a T-cell surface molecule, CD45RO, in 119 infants, 8 of whom had an intrauterine infection diagnosed antenatally. CD45RO was expressed on fewer than 10% of T cells in control infants and on more than 17% of T cells from infants with known infection (p < 0.006). This method allows screening of infants for infection by a range of organisms as a cause of their infection.

MeSH terms

  • Female
  • Fetal Blood
  • Flow Cytometry
  • Humans
  • Infant, Newborn
  • Infections / blood
  • Infections / congenital*
  • Leukocyte Common Antigens / blood*
  • Male


  • Leukocyte Common Antigens