Amplitude fluctuations of dual-component EPSCs in hippocampal pyramidal cells: implications for long-term potentiation

Neuron. 1994 May;12(5):1111-20. doi: 10.1016/0896-6273(94)90318-2.


Quantal analysis has provided evidence for a presynaptic contribution to long-term potentiation in hippocampal CA1 cells. This however leaves unexplained the observation that long-term potentiation has little or no effect on the NMDA receptor-mediated component of the synaptic signal. Here, I report that, in baseline conditions, the coefficient of variation of the AMPA/kainate receptor-mediated signal (CVA/K) is consistently larger than that of the NMDA component (CVNMDA), a result which can be explained if AMPA/kainate receptors are absent or nonfunctional at a proportion of synapses. Long-term potentiation is associated with a reduction in CVA/K, but no change in either the average amplitude of the NMDA component or CVNMDA. This is consistent with the proposal that long-term potentiation induction uncovers clusters of latent AMPA/kainate receptors, with no change in transmitter release.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Amino-5-phosphonovalerate / pharmacology
  • Anesthetics, Local / pharmacology
  • Animals
  • Evoked Potentials / drug effects
  • Evoked Potentials / physiology*
  • Guinea Pigs
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Lidocaine / analogs & derivatives
  • Lidocaine / pharmacology
  • Long-Term Potentiation / drug effects
  • Long-Term Potentiation / physiology*
  • Nerve Fibers / drug effects
  • Nerve Fibers / physiology
  • Pyramidal Cells / drug effects
  • Pyramidal Cells / physiology*
  • Quinoxalines / pharmacology
  • Receptors, AMPA / physiology
  • Receptors, Kainic Acid / physiology
  • Receptors, N-Methyl-D-Aspartate / drug effects
  • Receptors, N-Methyl-D-Aspartate / physiology
  • Synapses / drug effects
  • Synapses / physiology


  • Anesthetics, Local
  • Quinoxalines
  • Receptors, AMPA
  • Receptors, Kainic Acid
  • Receptors, N-Methyl-D-Aspartate
  • QX-314
  • FG 9041
  • 2-Amino-5-phosphonovalerate
  • Lidocaine