Transcriptional regulation of T-cell genes during T-cell development

Curr Opin Immunol. 1994 Apr;6(2):231-7. doi: 10.1016/0952-7915(94)90096-5.


The expression of many T cell specific genes has been shown to be regulated at the transcriptional level. Recent studies of T-cell specific promoters and enhancers have allowed the identification of a number of transcription factors that appear to play distinct but complementary roles in regulating gene expression during T-cell development and activation.

Publication types

  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Chromatin / metabolism
  • Gene Expression Regulation / physiology*
  • Genes, Homeobox / physiology
  • Helix-Loop-Helix Motifs / physiology
  • High Mobility Group Proteins / physiology
  • Immune System / growth & development*
  • Molecular Sequence Data
  • T-Lymphocytes / physiology*
  • Transcription Factors / physiology*
  • Zinc Fingers / genetics


  • Chromatin
  • High Mobility Group Proteins
  • Transcription Factors