The effect of chloramphenicol and sulphaphenazole on the biotransformation of cyclophosphamide in man

Br J Clin Pharmacol. 1975 Jun;2(3):281-5. doi: 10.1111/j.1365-2125.1975.tb01589.x.


1 The metabolism of cyclophosphamide was investigated before and following treatment with chloramphenicol (five subject) and sulphaphenazole (seven subjects). 2 The biotransformation of cyclophosphamide was retarded after chloramphenicol treatment as indicated by prolongation in the mean serum half-life from 7.5 h to 11.5 h combined with decreased peak activity and integrated concentrations of metabolites. 3 In the sulphaphenazole treated subjects the rate of biotransformation of cyclophosphamide was significantly inhibited in two, unaltered in three and enhanced in two. The inconsistency of the results is discussed.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Aged
  • Biotransformation / drug effects
  • Chloramphenicol / pharmacology*
  • Clinical Trials as Topic
  • Cyclophosphamide / metabolism*
  • Female
  • Half-Life
  • Humans
  • Male
  • Middle Aged
  • Sulfaphenazole / pharmacology*


  • Sulfaphenazole
  • Chloramphenicol
  • Cyclophosphamide