Study of B and T cell phenotypes in blood from patients with common variable immunodeficiency (CVID)

Immunodeficiency. 1994;5(2):159-69.


B and T cell phenotypes in peripheral blood from 71 CVID patients have been measured in a study using directly conjugated monoclonal antibodies and two colour flow cytometry. Data was compared between different patient groups (based on whether their B cells could secrete IgM or IgG in vitro) and normal donors. There was a clear correlation between abnormalities of both B and T cells and the different patient groups. There were reduced absolute numbers of circulating CD4+ T cells, particularly those of the CD4+.CD45RA+ subset, and of CD19+ B cells in those patients whose B cells failed to secrete IgM or IgG in vitro. This demonstrates an association between B cell lymphopenia, failure of B cell immunoglobulin production in vitro and T cell subset lymphopenia in CVID. It supports the view that this group of CVID patients has a disease involving T cell regulation of B cells of varying severity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal
  • B-Lymphocytes / immunology*
  • CD3 Complex / immunology
  • CD4-CD8 Ratio
  • CD4-Positive T-Lymphocytes / immunology
  • Common Variable Immunodeficiency / immunology*
  • Flow Cytometry
  • Humans
  • Immunophenotyping
  • Leukocyte Count
  • Lymphopenia / immunology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes, Regulatory / immunology


  • Antibodies, Monoclonal
  • CD3 Complex