Molecular genetic analysis of the primary immunodeficiency disorders

D L Nelson; C C Kurman

doi:10.1016/s0031-3955(16)38802-2

Molecular genetic analysis of the primary immunodeficiency disorders

Pediatr Clin North Am. 1994 Aug;41(4):657-64. doi: 10.1016/s0031-3955(16)38802-2.

Authors

D L Nelson¹, C C Kurman

Affiliation

¹ Immunophysiology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

PMID: 7914021
DOI: 10.1016/s0031-3955(16)38802-2

Abstract

Exciting progress in the search for the genetic basis of the primary immune deficiency disorders continues to shed insight into functioning of the immune system in health and disease. The molecular genetic causes of 7 of the 17 WHO-recognized primary immune deficiency diseases have been defined. Additional studies will shed more insight into congenital and acquired immune deficiency disorders.

Publication types

Review

MeSH terms

Chromosome Mapping
Genetic Carrier Screening / methods
Humans
Immunologic Deficiency Syndromes / classification
Immunologic Deficiency Syndromes / diagnosis
Immunologic Deficiency Syndromes / genetics*
Immunologic Deficiency Syndromes / immunology
Molecular Biology / methods
Polymorphism, Restriction Fragment Length
Prenatal Diagnosis / methods