Abducens nerve responses of the frog during horizontal linear acceleration: data and model

Biol Cybern. 1994;70(6):533-40. doi: 10.1007/BF00198806.

Abstract

Abducens nerve responses of frogs were evoked by sinusoidal oscillations on a horizontal linear sled. The depth of modulation of these responses and their phases depended on the orientation of the head with respect to the direction of linear acceleration. Longitudinal acceleration evoked abducens responses that consisted of two discharge maxima per stimulus cycle. At consecutively more oblique head orientations, one of these two discharge maxima increased and the other decreased. Transverse accelerations evoked abducens responses that consisted of only one discharge maximum per stimulus cycle. Removal of the labyrinthine organs on one side abolished these responses in the contralateral abducens nerve but did not affect the responses in the ipsilateral abducens nerve. The latter result indicates that the responses in each abducens nerve originate from hair cells on the contralateral utricle. The experimentally determined modulation and phase values and their dependence on the orientation angle of the acceleration vector were used to characterize a functional cluster of hair cells located medially with respect to the striola in a fan-like sector on the utricle ('lateral rectus fan'). Parameters of this fan were used to develop a model that satisfactorily simulates the recorded abducens responses. This model predicts a majority of afferents with excitatory and a few afferents with inhibitory contributions to the abducens nerve responses. The phasic response components of about 90% of these afferents are larger than their tonic response components.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abducens Nerve / physiology*
  • Acceleration*
  • Acoustic Maculae / physiology
  • Animals
  • Cybernetics
  • Evoked Potentials / physiology
  • Eye Movements / physiology
  • Locomotion / physiology
  • Models, Neurological
  • Rana temporaria / physiology