Antipsychotic drugs: is more worse? A meta-analysis of the published randomized control trials

Psychol Med. 1994 May;24(2):307-16. doi: 10.1017/s003329170002729x.


Effectiveness and side-effects of high- versus low-dose neuroleptic treatment of chronic psychosis have been assessed through a meta-analysis of 22 published randomized control trials comparing different neuroleptic doses. No incremental clinical improvement was found at doses above 375 mg equivalent of chlorpromazine, while a significant increase in adverse reactions was observed.

Publication types

  • Comparative Study
  • Meta-Analysis
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antipsychotic Agents / administration & dosage
  • Antipsychotic Agents / adverse effects*
  • Chlorpromazine / administration & dosage
  • Chlorpromazine / adverse effects
  • Chronic Disease
  • Dose-Response Relationship, Drug
  • Dyskinesia, Drug-Induced / etiology
  • Humans
  • Psychotic Disorders / drug therapy*
  • Psychotic Disorders / psychology
  • Randomized Controlled Trials as Topic
  • Treatment Outcome


  • Antipsychotic Agents
  • Chlorpromazine