Control of cell pattern in the neural tube: regulation of cell differentiation by dorsalin-1, a novel TGF beta family member

Cell. 1993 May 21;73(4):687-702. doi: 10.1016/0092-8674(93)90249-p.


Distinct cell types differentiate along the dorsoventral axis of the neural tube. We have cloned and characterized a novel member of the TGF beta gene family, dorsalin-1 (dsl-1), that appears to regulate cell differentiation within the neural tube. dsl-1 is expressed selectively in the dorsal neural tube, and its pattern of expression appears to be restricted by early signals from the notochord. Exposure of neural plate cells to dsl-1 promotes the differentiation of cells with neural crest-like properties and inhibits the induction of motor neurons by signals from the notochord and floor plate. These findings suggest that dsl-1 regulates the differentiation of cell types along the dorsoventral axis of the neural tube, acting in conjunction with distinct ventralizing signals from the notochord and floor plate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Bone Morphogenetic Proteins
  • Cell Differentiation
  • Cell Line
  • Chick Embryo
  • Models, Neurological
  • Molecular Sequence Data
  • Motor Neurons / cytology
  • Nervous System / embryology*
  • Neural Crest / cytology
  • Notochord / metabolism
  • Proteins
  • RNA, Messenger / metabolism
  • Sequence Homology, Amino Acid
  • Transforming Growth Factors / genetics*
  • Transforming Growth Factors / physiology*


  • Bone Morphogenetic Proteins
  • Proteins
  • RNA, Messenger
  • dorsalin 1 protein, Gallus gallus
  • Transforming Growth Factors

Associated data

  • GENBANK/L12032
  • GENBANK/L14567
  • GENBANK/L14568
  • GENBANK/L14569
  • GENBANK/L33709
  • GENBANK/S60902
  • GENBANK/S60903
  • GENBANK/S60904
  • GENBANK/S60905
  • GENBANK/S60924