The fission yeast cdc18+ gene product couples S phase to START and mitosis

Cell. 1993 Jul 30;74(2):371-82. doi: 10.1016/0092-8674(93)90427-r.


Commitment to the cell cycle in fission yeast requires the function of the cdc10+ transcriptional activator at START. The product of the cdc18+ gene is a major downstream target of cdc10+, and transcription of cdc18+ is activated by cdc10+ during passage through START. The cdc18+ function is required for entry into S phase. In addition, the product of the cdc18+ gene is part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Thus, cdc18+ plays a key role in coupling S phase to START and mitosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cell Cycle / genetics*
  • Cell Cycle Proteins*
  • Cloning, Molecular
  • Fungal Proteins / genetics*
  • Fungal Proteins / metabolism
  • Gene Deletion
  • Genes, Fungal / genetics*
  • Mitosis / genetics
  • Models, Genetic
  • Molecular Sequence Data
  • Periodicity
  • Phenotype
  • S Phase / genetics
  • Schizosaccharomyces / genetics*
  • Schizosaccharomyces pombe Proteins
  • Sequence Homology, Amino Acid
  • Suppression, Genetic
  • Transcription Factors
  • Transcription, Genetic


  • Cell Cycle Proteins
  • Fungal Proteins
  • Schizosaccharomyces pombe Proteins
  • Transcription Factors
  • cdc10 protein, S pombe
  • cdc18 protein, S pombe

Associated data

  • GENBANK/L14569
  • GENBANK/L16793
  • GENBANK/L19248
  • GENBANK/L19249
  • GENBANK/L33709
  • GENBANK/S60902
  • GENBANK/S60903
  • GENBANK/S60904
  • GENBANK/S60905
  • GENBANK/S60924