Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1

FEBS Lett. 1993 Feb 22;318(1):83-7. doi: 10.1016/0014-5793(93)81333-u.


In the course of studying the ST2 gene, which was initially found to be expressed specifically at the G0/G1 transitional state in BALB/c-3T3 cells and was one of the primary response genes, we found another ST2-related mRNA, designated as ST2L, in serum-stimulated BALB/c-3T3 cells in the presence of cycloheximide. Nucleotide sequence analysis of the cloned ST2L cDNA revealed that it had an open reading frame encoding a polypeptide of 567 amino acids. A 5' region (1,028 nucleotides) of ST2L cDNA was identical with the ST2 cDNA, and a unique 3' region encoded a putative transmembrane domain of 24 amino acids and a cytoplasmic domain of 201 amino acids. The ST2 gene product is highly similar to the extracellular portion of IL-1 receptors type 1 and type 2, and the ST2L gene product shows a marked similarity with entire IL-1 receptor type 1.

MeSH terms

  • 3T3 Cells
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • DNA
  • Interleukin-1 Receptor-Like 1 Protein
  • Membrane Proteins*
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Proteins / genetics*
  • Receptors, Interleukin
  • Receptors, Interleukin-1 / genetics*
  • Sequence Homology, Amino Acid


  • Il1rl1 protein, mouse
  • Interleukin-1 Receptor-Like 1 Protein
  • Membrane Proteins
  • Proteins
  • Receptors, Interleukin
  • Receptors, Interleukin-1
  • DNA

Associated data

  • GENBANK/D13695
  • GENBANK/L03647
  • GENBANK/L03648
  • GENBANK/L03649
  • GENBANK/L03650
  • GENBANK/L03651
  • GENBANK/L03652
  • GENBANK/L03653
  • GENBANK/L03654
  • GENBANK/Z19541