The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases

Immunol Today. 1994 Aug;15(8):356-61. doi: 10.1016/0167-5699(94)90173-2.


A variety of experimental approaches are currently being evaluated for controlling CD4+ T helper 1 (Th1)-mediated autoimmune pathology. Here, Stephen Miller and William Karpus compare and contrast the efficacies of various antigen-specific regulatory strategies. Particular emphasis is placed on the mechanisms of peripheral immune tolerance and how this may be used in the treatment and analysis of the pathologic T-cell repertoire in autoimmune and virus-induced demyelinating diseases.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Demyelinating Diseases / immunology*
  • Disease Models, Animal
  • Humans
  • Immune Tolerance
  • T-Lymphocytes, Helper-Inducer / immunology*