Spatial and temporal changes in signal transduction pathways during LTP

Neuron. 1994 Sep;13(3):737-45. doi: 10.1016/0896-6273(94)90040-x.


Following LTP induction in freely moving rats, in situ hybridization revealed discrete changes in the expression of one isoform in each of four families of serine/threonine kinases constitutively expressed in the dentate gyrus of the hippocampus. Expression of the alpha isoform of CaMKII showed a transient increase over the soma and a more persistent increase over the dendritic field of dentate granule cells. Of the PKC isoforms, only gamma PKC was up-regulated substantially 2 hr after LTP induction, declining to control levels 48 hr later. An increase in the expression of mRNA for ERK2 and raf-B was seen at 24 hr only. These results show that, during the maintenance phase of LTP in the hippocampus, there are selective increases in the expression of serine/threonine kinases and that these increases have specific and characteristic temporal and spatial profiles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism
  • Dendrites / enzymology
  • Gene Expression Regulation
  • Genes, Immediate-Early
  • Granulocytes / enzymology
  • Hippocampus / enzymology
  • Hippocampus / physiology
  • Isoenzymes / metabolism
  • Long-Term Potentiation*
  • Protein Kinase C / metabolism
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Signal Transduction*
  • Time Factors


  • Isoenzymes
  • RNA, Messenger
  • Protein Kinase C
  • Calcium-Calmodulin-Dependent Protein Kinases