The SNF/SWI family of global transcriptional activators

Curr Opin Cell Biol. 1994 Jun;6(3):396-402. doi: 10.1016/0955-0674(94)90032-9.

Abstract

The yeast SNF/SWI proteins have a global role in transcriptional activation. This set of five proteins assists many gene-specific activators, most likely by altering chromatin structure to relieve repression. Recent work shows that the SNF/SWI proteins function together in a multiprotein complex and that SNF2 has DNA-dependent ATPase activity. SNF/SWI homologs have now been identified in Drosophila, mice and humans, suggesting a conserved role in transcriptional activation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chromosomal Proteins, Non-Histone
  • DNA / genetics
  • DNA, Fungal / genetics
  • Drosophila / genetics
  • Fungal Proteins / genetics
  • Fungal Proteins / physiology
  • Humans
  • Mice
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae Proteins
  • Trans-Activators / genetics
  • Trans-Activators / physiology*
  • Transcription Factors / genetics
  • Transcription Factors / physiology*
  • Transcriptional Activation*

Substances

  • Chromosomal Proteins, Non-Histone
  • DNA, Fungal
  • Fungal Proteins
  • SWI1 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Trans-Activators
  • Transcription Factors
  • DNA