Wiring diagrams: regulatory circuits and the control of skeletal myogenesis

Curr Opin Cell Biol. 1994 Jun;6(3):432-42. doi: 10.1016/0955-0674(94)90037-x.

Abstract

During the past year, targeted mutagenesis in mice has begun to clarify the roles of individual members of the MyoD family of myogenic regulators in vertebrate development. In this review, we discuss these studies both in the context of tissue interactions necessary to induce skeletal muscle precursor cells during embryogenesis and the molecular circuitry that regulates the terminal differentiation of these cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology
  • DNA / genetics
  • DNA / physiology
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology
  • Gene Expression Regulation / genetics
  • Gene Expression Regulation / physiology
  • Helix-Loop-Helix Motifs / genetics
  • Helix-Loop-Helix Motifs / physiology
  • Humans
  • MEF2 Transcription Factors
  • Muscles / cytology*
  • Muscles / embryology*
  • Muscles / physiology
  • Myogenic Regulatory Factors
  • Regulatory Sequences, Nucleic Acid / genetics
  • Regulatory Sequences, Nucleic Acid / physiology*
  • Transcription Factors / genetics
  • Transcription Factors / physiology*

Substances

  • DNA-Binding Proteins
  • MEF2 Transcription Factors
  • Myogenic Regulatory Factors
  • Transcription Factors
  • DNA