Cell cycle regulated transcription in yeast

Curr Opin Cell Biol. 1994 Jun;6(3):451-9. doi: 10.1016/0955-0674(94)90039-6.


At least four different classes of cell cycle regulated gene exist in yeast: G1 cyclins and DNA synthesis genes are expressed in late G1; histone genes in S phase; genes for transcription factors, cell cycle regulators and replication initiation proteins in G2; and genes needed for cell separation as cells enter G1. Early and late G1-specific transcription is mediated by the Swi5/Ace2 and Swi4/Swi6 classes of factor, respectively. Changes in cyclin/Cdc28 kinases may be involved in all classes of regulation. Transcriptional control of cyclin genes has an important role in regulating cell cycle progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • DNA, Fungal / analysis
  • DNA, Fungal / genetics
  • Gene Expression Regulation, Fungal / genetics
  • Gene Expression Regulation, Fungal / physiology
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / physiology*
  • Transcription, Genetic / physiology*


  • DNA, Fungal