Clinical observations on the use of the Chinese herb Tripterygium wilfordii Hook for the treatment of nephrotic syndrome

Pediatr Nephrol. 1994 Jun;8(3):343-4. doi: 10.1007/BF00866356.


A preparation of extracts from the root of the Chinese medicinal herb Tripterygium wilfordii Hook was administered orally at a dose of 1 mg/kg body weight per day to 13 children with idiopathic nephrotic syndrome. Eight children, including 4 who were steroid resistant, went into remission which was maintained in 4 for up to 3 years after withdrawal of treatment. In 3 children the proteinuria lessened with the return of plasma protein concentration to normal, and in 1 child this improvement was maintained for 4 years after treatment ceased. No serious side-effects were noted, but a temporary anti-fertility activity has been noted in other studies of both men and women.

MeSH terms

  • Administration, Oral
  • Child, Preschool
  • Drugs, Chinese Herbal / administration & dosage
  • Drugs, Chinese Herbal / therapeutic use*
  • Humans
  • Nephrotic Syndrome / drug therapy*
  • Recurrence
  • Remission Induction


  • Drugs, Chinese Herbal