Expression and distribution of transforming growth factor-beta and decorin during fracture healing

In Vivo. Mar-Apr 1994;8(2):215-9.


To study interactions between TGF-beta and decorin, we experimentally induced femoral fracture in rats and immunohistologically examined changes in the distribution of TGF-beta and decorin in the femur 3, 7 and 14 days after fracture. In the areas where endochondral ossification occurred, decorin was detected during differentiation of mesenchymal cells into proliferating chondrocytes, while no TGB-beta was observed during same period. Once chondrocytes had hypertrophied, decorin was no longer observed, while the matrix around the hypertrophic chondrocytes was positively stained for TGB-beta. The disappearance of decorin, almost simultaneously accompanied by the appearance of the active type TGB-beta, suggests that decorin regulates the actions of TGB-beta.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Decorin
  • Extracellular Matrix Proteins
  • Femoral Fractures / metabolism*
  • Femoral Fractures / physiopathology
  • Fracture Healing / physiology
  • Proteoglycans / metabolism*
  • Rats
  • Rats, Wistar
  • Transforming Growth Factor beta / metabolism*


  • Decorin
  • Extracellular Matrix Proteins
  • Proteoglycans
  • Transforming Growth Factor beta