Calcium channels: cellular roles and molecular mechanisms

Curr Opin Neurobiol. 1994 Jun;4(3):304-12. doi: 10.1016/0959-4388(94)90090-6.


An unexpected variety of different types of Ca2+ channels have been identified using molecular cloning and selective Ca2+ channel toxins. A main focus of current research in this field is to characterize these different channel types and the molecular mechanisms by which Ca2+ channels perform their basic activities of gating, selectivity and modulation. Recent advances demonstrate the roles of different types of Ca2+ channels in muscle and nerve, and provide hints about the structures involved in selectivity and gating.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium Channels / chemistry
  • Calcium Channels / classification
  • Calcium Channels / physiology*
  • Humans
  • Ion Channel Gating
  • Structure-Activity Relationship
  • Synaptic Transmission / physiology


  • Calcium Channels