An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus

Nat Genet. 1994 Jul;7(3):383-9. doi: 10.1038/ng0794-383.

Abstract

The T locus encodes a product with DNA binding activity that is likely to play a role in the development of all vertebrate organisms. We have identified and characterized a novel family of mouse genes that share a protein motif, the T-box, with the prototypical T locus. The T-box domain of the T locus co-localizes with its DNA binding activity. Each T-box gene is expressed in a unique temporal and spatial pattern during embryogenesis. Phylogenetic analysis suggests that at least three T-box genes were present in the common ancestor to vertebrates and invertebrates. Thus, members of the T-box family could have played a role in the evolution of all metazoan organisms.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA-Binding Proteins / biosynthesis
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / physiology
  • Drosophila / genetics
  • Drosophila Proteins*
  • Embryonic and Fetal Development / genetics*
  • Fetal Proteins / biosynthesis
  • Fetal Proteins / chemistry
  • Fetal Proteins / genetics*
  • Fetal Proteins / physiology
  • Gene Expression Regulation
  • Genes
  • Genes, Insect
  • Genes, Lethal
  • Invertebrates / embryology
  • Invertebrates / genetics*
  • Invertebrates / growth & development
  • Mesoderm
  • Mice / embryology
  • Mice / genetics*
  • Mice / growth & development
  • Molecular Sequence Data
  • Multigene Family*
  • Nerve Tissue Proteins / genetics
  • Phylogeny
  • Polymerase Chain Reaction
  • Protein Structure, Tertiary*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Species Specificity
  • T-Box Domain Proteins*
  • Vertebrates / embryology
  • Vertebrates / genetics*
  • Vertebrates / growth & development

Substances

  • DNA-Binding Proteins
  • Drosophila Proteins
  • Fetal Proteins
  • Nerve Tissue Proteins
  • T-Box Domain Proteins
  • bi protein, Drosophila
  • Brachyury protein

Associated data

  • GENBANK/U15565
  • GENBANK/U15566
  • GENBANK/U15567