High-level multilineage engraftment of human cord blood cells in SCID mice

J Hematother. 1993 Summer;2(2):215-6. doi: 10.1089/scd.1.1993.2.215.

Abstract

Cord blood is increasingly used as an alternative to bone marrow transplantation in pediatric patients. Therefore, to study cord blood-derived hematopoiesis in vivo we are developing a xenogeneic transplantation model using immunodeficient SCID mice.

MeSH terms

  • Animals
  • Bone Marrow / pathology
  • Colony-Forming Units Assay
  • Fetal Blood / cytology*
  • Graft Survival
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Infant, Newborn
  • Mice
  • Mice, SCID*
  • Radiation Chimera
  • Severe Combined Immunodeficiency / therapy*
  • Transplantation, Heterologous