Muscle differentiation. Which myogenic factors make muscle?

Curr Biol. 1994 Jan 1;4(1):61-3. doi: 10.1016/s0960-9822(00)00014-2.

Abstract

Mice lacking myogenin have little skeletal muscle as fibres fail to differentiate. Lack of both MyoD and myf-5 results in no skeletal muscle and apparently no myoblasts, suggesting that these factors act earlier in muscle development.

MeSH terms

  • Animals
  • Cell Differentiation
  • DNA-Binding Proteins*
  • Embryonic and Fetal Development
  • Gene Expression
  • Mice
  • Mice, Mutant Strains
  • Muscle Fibers, Skeletal / physiology
  • Muscle Proteins / biosynthesis
  • Muscle Proteins / physiology*
  • Muscles / cytology
  • Muscles / embryology
  • Muscles / physiology*
  • MyoD Protein / biosynthesis
  • MyoD Protein / physiology*
  • Myogenic Regulatory Factor 5
  • Myogenin / physiology*
  • Trans-Activators*
  • Transcription Factors / physiology*

Substances

  • DNA-Binding Proteins
  • Muscle Proteins
  • Myf5 protein, mouse
  • MyoD Protein
  • Myog protein, mouse
  • Myogenic Regulatory Factor 5
  • Myogenin
  • Trans-Activators
  • Transcription Factors