Fibroadenoma of the breast showing a translocation (6;14), a ring chromosome and two markers involving parts of chromosome 11

Cancer Genet Cytogenet. 1994 Sep;76(2):145-7. doi: 10.1016/0165-4608(94)90466-9.

Abstract

The cytogenetic findings of a recurrent fibroadenoma of a 25-year-old woman are reported. Of 58 metaphases karyotyped after G-banding, 27 showed an apparently normal karyotype and 31 the karyotype 48,XX,del(6)(q21),r(11)(?) + der(11)x2,der(14)t(6;14)(q21;q32). By fluorescence in situ hybridization studies using a chromosome 11 specific painting probe, we were able to show that the two marker chromosomes and the ring contained chromosome 11 DNA.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Breast Neoplasms / genetics*
  • Chromosome Aberrations*
  • Chromosomes, Human, Pair 11*
  • Chromosomes, Human, Pair 14*
  • Chromosomes, Human, Pair 6*
  • Female
  • Fibroadenoma / genetics*
  • Genetic Markers
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Ring Chromosomes
  • Translocation, Genetic

Substances

  • Genetic Markers