A characteristic change in ventilation mode during exertional dyspnea in patients with chronic heart failure

Chest. 1994 Oct;106(4):1007-13. doi: 10.1378/chest.106.4.1007.


Although exertional dyspnea is an important symptom limiting daily lives in patients with chronic heart failure, there is no objective assessment of this symptom. To characterize the exertional dyspnea, ventilatory responses to exercise were studied in relation to exertional dyspnea. Gas exchange data were obtained during a maximal bicycle exercise in 43 patients with chronic heart failure and 20 normal subjects. In addition to standard ventilatory variables, the ventilation mode was assessed from the tidal volume-ventilation rate (VT-f) relationship. The exercise was performed again after sublingual administration of 5 mg of isosorbide dinitrate. In normal subjects, the f and VT increased almost proportionally with exercise intensity. In 17 (85 percent) of 20 patients with exertional dyspnea, the VT-f relationship abruptly lost linearity at the onset of exertional dyspnea. This change resulted from an inadequate increase in VT and a further increase in f. In 8 of these 17 patients, isosorbide dinitrate improved exertional dyspnea with normalization of the VT-f relationship; however, in 9 patients whose dyspnea was not improved, the abnormal VT-f relationship was unaltered. Only 2 (9 percent) of 23 patients without exertional dyspnea showed the abnormal VT-f relationship. Other ventilatory variables were not different between patients with and without dyspnea. Thus, exertional dyspnea is characterized by simultaneous appearance of rapid and shallow ventilation. The VT-f relationship appears to be a simple and useful objective assessment of exertional dyspnea in patients with chronic heart failure.

MeSH terms

  • Dyspnea / physiopathology*
  • Dyspnea / prevention & control
  • Exercise Test
  • Exercise Tolerance / physiology*
  • Female
  • Heart Failure / diagnosis
  • Heart Failure / physiopathology*
  • Humans
  • Isosorbide Dinitrate / pharmacology
  • Male
  • Middle Aged
  • Pulmonary Gas Exchange / physiology
  • Reproducibility of Results
  • Respiration / drug effects
  • Respiration / physiology
  • Tidal Volume / physiology


  • Isosorbide Dinitrate