Abstract
The bioavailability of two oral preparations of pyrimethamine-sulfadoxine are compared in a randomised cross-over study. Pyrimethamine(PM)-sulfadoxine(SD) was given orally in a single dose to healthy male adults (SD 12 mgkg-1; PM 0.64 mgkg-1). For Fansidar(Hoffman-LaRoche) the mean AUC for PM and SD were; 0.47 mghl-1 and 45.4 mghl-1, and for Falcidin(Cosmos), the mean AUC for PM and SD were; 0.49 mg hl-1 and 42.9 mghl-1 respectively. There was no significant difference in bioavailability of PM or SD between the two preparations.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Adult
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Antimalarials / blood
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Antimalarials / pharmacokinetics*
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Antimalarials / supply & distribution
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Biological Availability
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Drug Combinations
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Humans
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Male
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Pyrimethamine / blood
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Pyrimethamine / pharmacokinetics*
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Pyrimethamine / supply & distribution
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Sulfadoxine / blood
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Sulfadoxine / pharmacokinetics*
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Sulfadoxine / supply & distribution
Substances
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Antimalarials
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Drug Combinations
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fanasil, pyrimethamine drug combination
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Sulfadoxine
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Pyrimethamine