Cell surface protein receptors in oral streptococci

FEMS Microbiol Lett. 1994 Aug 15;121(2):133-40. doi: 10.1111/j.1574-6968.1994.tb07089.x.

Abstract

Streptococci have a vast repertoire of adherence properties which include binding to human tissue components, epithelial cells and to other bacterial cells. These interactions are determined by the expression of cell-surface receptors some of which are species-specific. In the oral streptococci, two families of surface protein receptors with highly conserved amino acid sequences have been identified. The antigen I/II family of polypeptides are wall-associated high molecular mass proteins (158-166 kDa) with several binding functions that may be attributed to different domains of the receptor molecules. The LraI family of polypeptides are surface-associated lipoproteins (32-33 kDa) involved in adherence of streptococci to salivary glycoprotein pellicle and to oral Actinomyces. A region of amino acid sequence similarity is evident amongst members of the two protein families in Streptococcus gordonii. Ligand-binding specificities of these receptor polypeptides may account for species-specific adherence and site-directed colonization of streptococci within the human oral cavity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adhesins, Bacterial / analysis*
  • Amino Acid Sequence
  • Antigens, Bacterial / analysis*
  • Bacterial Adhesion*
  • Bacterial Outer Membrane Proteins / analysis
  • Bacterial Proteins / analysis*
  • Carrier Proteins*
  • Fimbriae Proteins*
  • Humans
  • Lipoproteins / analysis
  • Lipoproteins / chemistry
  • Membrane Glycoproteins*
  • Membrane Proteins*
  • Membrane Transport Proteins*
  • Molecular Sequence Data
  • Mouth / microbiology*
  • Receptors, Cell Surface / analysis*
  • Sequence Alignment
  • Streptococcus / chemistry*
  • Streptococcus / isolation & purification

Substances

  • Adhesins, Bacterial
  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • Carrier Proteins
  • Lipoproteins
  • Membrane Glycoproteins
  • Membrane Proteins
  • Membrane Transport Proteins
  • PsaA protein, Streptococcus
  • Receptors, Cell Surface
  • S-layer proteins
  • ScaA protein, Streptococcus gordonii
  • fimbrillin
  • saliva-binding protein, Streptococcus sanguis 12
  • Fimbriae Proteins