Cloning of the cDNA Encoding Rat Tissue Inhibitor of Metalloproteinase 1 (TIMP-1), Amino Acid Comparison With Other TIMPs, and Gene Expression in Rat Tissues

Gene. 1994 Sep 30;147(2):301-2. doi: 10.1016/0378-1119(94)90088-4.


We have cloned the cDNA encoding the rat tissue inhibitor of metalloproteinase 1 (TIMP-1) from a cDNA library derived from healing skin wounds. The deduced amino acid (aa) sequence shows 66, 35 and 34% identity with human TIMP-1 and TIMP-2, and chicken TIMP-3 aa sequences, respectively. High-level expression of rat TIMP-1 RNA was detected in the skin wounds and in normal ovary.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA, Complementary
  • Gene Expression
  • Glycoproteins / genetics*
  • Humans
  • Molecular Sequence Data
  • Rats
  • Sequence Homology, Amino Acid
  • Tissue Inhibitor of Metalloproteinases


  • DNA, Complementary
  • Glycoproteins
  • Tissue Inhibitor of Metalloproteinases

Associated data

  • GENBANK/U06179