Ageing in amphibians

Gerontology. 1994;40(2-4):161-73. doi: 10.1159/000213585.


Limited research findings up-to-date with a few amphibian models do not permit a generalisation of ageing phenomena in the class Amphibia. Short-lived species of amphibians show gradual senescence comparable to the pattern seen in laboratory mammals. Long-lived species (mostly urodeles) continue to grow throughout life and are believed to exhibit very slow or negligible senescence which is unobtrusive. In a few species with gradual senescence, there is some evidence of an increase in mortality rate and a decrease in growth rate with advancing age. Increase in cross-linking of collagen, accumulation of age pigments (lipofuscin and melanin), decrease in metabolism and loss of immunocompetence are ageing phenomena common to both amphibians and mammals. On the other hand, persistence of neurogenesis and myogenesis, continuance of oogenesis beyond adult life and polyphyodonty are some of the features peculiar to ageing in amphibians. More authenticated reports are needed to fill up the gaps in our knowledge on amphibian senescence.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Aging / pathology
  • Aging / physiology*
  • Amphibians / anatomy & histology
  • Amphibians / growth & development
  • Amphibians / physiology*
  • Animals
  • Behavior, Animal
  • Collagen / metabolism
  • Female
  • Longevity
  • Male
  • Regeneration
  • Reproduction


  • Collagen